Find out more about the research and projects supported by the BCI

A randomised control trial of breast-conserving surgery with or without irradiation in women aged 65 years or older with early breast cancer.

The role of postmastectomy radiotherapy in intermediate-risk breast cancer (BIG 2.04 MRC SUPREMO trial).

A randomized phase III study of radiation doses and fractionation schedules for Ductal Carcinoma in Situ (DCIS) of the breast.

Genomics of endocrine therapy resistance: tailoring treatment using personalised genomic analysis in ER-positive breast cancer.

This project aims to better understand the mechanisms behind breast cancer recurrence. Targeted DNA sequencing and transcriptomic analysis will be used to study recurrent breast cancers.

Study to develop an approach for genomic in vitro analysis of fresh tumour samples to assess drug response and inform treatment choice.

Analysing and evaluating the combination effects of Carbonic anhydrase IX (CAIX) inhibition in conjunction with radiotherapy.

Comprehensive profiling of clonal dynamics in longitudinal TNBC samples from early disease to metastatic setting.

Validation of a predictive gene expression signature for radiotherapy in breast cancer and study of the underlying mechanisms of resistance for potential therapeutic intent.

Translational pre-clinical study to investigate novel radio-sensitivity predictive biomarkers in breast cancer.

Predicting local recurrence in patients treated for ductal carcinoma in situ (DCIS).

This project will study lobular breast cancers treated with endocrine therapy to investigate how the effects of interleukin-6 change during treatment. The aim is to help identify potential new treatment options for lobular breast cancer.

Study to explore the mechanisms underlying differential response to treatment in primary tumours versus nodal metastasis. With the aim of improving prediction of response to treatment.

Molecular signatures of radiosensitivity and ipsilateral breast tumour recurrence in breast cancer.

Pilot study, to investigate the potential value of microwave radiometry for breast cancer diagnosis and the prediction of prognosis.

Quantification of long term adverse cardiac outcomes in breast cancer survivors treated with and without anthracycline chemotherapy.

Edinburgh Health Economics Info-BC project is looking to discover what matters most to patients when receiving treatment for secondary breast cancer.

A natural experiment using Scottish clinical data to estimate the real-world effectiveness of adjuvant chemotherapy in breast cancer patients

Research study to independently validate the updated PREDICT breast cancer prognostic model using routine Scottish data

The BCI supported the renovation of the Edinburgh Breast Unit and waiting room for the benefit of our patients.

The BCI contributed to the redevelopment and expansion of ward 1 (chemotherapy unit) and clinical trials unit at the Western General Hospital

This grant supports costs associated with clinical research infrastructure at the Edinburgh Breast Unit including a funding for a dedicated research nurse to support all research within the unit.

The BCI is funding a 2-year research nurse post within the Edinburgh Breast Unit to facilitate and support the research portfolio within the unit.

From a specific donation made by a BCI supporter and her group of dedicated fundraisers the BCI has purchased a robotic sample processor which automates the extraction of DNA and RNA from tissue samples and facilitates much of the on-going reserach at the Edinburgh Breast Unit.

The BCI is funding a 3-year PhD studentship at the University of Edinburgh to explore the genomics underlying the response to treatment in metastatic disease.

This project will embed an early-career researcher within the Edinburgh Breast Unit for 3 years to conduct an economic evaluation of Complex Digital Interventions in Breast Cancer Care.

With the support of the BCI a local team at the Edinburgh Cancer Center have brought the 5K Your Way: Move Against Cancer Initiative to Edinburgh to inspire and empower people impacted by cancer to live an active and fulfilling lifestyle.